A differentiated effect of the Low-Temperature
Nano-Extraction method!

Low temperature nano-extraction Technology!

The JW brands are oriented towards the highest products in the world.

Major Study History

주요 연구이력
Items Contents
Publication of a research paper in Recent Medicine Topical application of JW12 and DANISS and its impact on hair loss prevention and hair growth for alopecia patients
Research Consortium of Industry-Academy-Research Co-op (Catholic Medical University of Daegu) JW12 or DANISS made from Algae and natural herb, their extraction of bioactive substances with hair restorer functionality and the validation of their clinical efficacy
Publication of a research paper in Recent Medicine Hair growth effect of JW12in the Mouse Model
Research Consortium of Industry-Academy-Research Co-op (Catholic Medical University of Daegu) the validation of hair growth mechanism of JW12 and DANISS, which has been developed for hair loss prevention and hair tonic, comparison with existing hair restorers, and application to actual patients
Symposium of the Korean Society of Plastic and Reconstructive Surgeons Presentation on the development and validation of JW12 , hair loss prevention
Gyeongbuk Marine Bio Technology Development (Kyunghee University) Development of the sanitary aid(hair loss prevention/ hair tonic/ hair growth solution) using algae and herb
Publication of a research paper in Recent Medicine
(Catholic Medical University of Daegu)		 Component Analysis of JW12 hair growth solution made from natural herb, extraction of hair growth accelerator, causal Analysis of hair growth, mouse models, and efficacy verification from actual patients
Publication of a research paper in Recent Medicine
(Catholic Medical University of Daegu)		 Analysis of the development and its effects of JW Tonic added with Copper peptide complex
Publication of a research paper in Recent Medicine
(Catholic Medical University of Daegu)		 Effective material extraction and the development of new hair restorer through the combination and analysis of major components of JW Tonic
Publication of a research paper in Recent Medicine
(Catholic Medical University of Daegu)		 Development of a new JW Tonic that is added with a hair growth factor and Validation of hair growth efficacy
Publication of a research paper in Recent Medicine
(Catholic Medical University of Daegu)		 the development and commercialization of hair loss prevention food through ultrasonic extraction
RIC(Regional Innovation Center) Common Task
(Catholic Medical University of Daegu)		 Functional materialization of seaweed polysaccharides and industrialization of through Ultra-high enzymatic extraction – anger extracted

The effect of a topical spray of JW12 and Daniss for the prevention of the hair loss and the promotion of the hair growth of the alopecia patients.(Sebum and dandruff removal, alopecia prevention, hair growth effect)

Recent Medicine, Vol. 47 Issue 7 (Professor Park, Dae Hwan, College of Medicine, Catholic University of Daegu)

Sebum and dandruff removal effect

Among 58 male and female subjects who participated in the clinical study, excessive sebum and dandruff were removed in most of the subjects within 2~3 weeks of use. After one month of use, all subjects showed normal status.

tonic_image1

Reduction in hair loss

Within 2~3 weeks, most (93%) of subjects showed significant reduction in hair loss.

tonic_image2

Hair growth

Hair growth effect with the thickening of hair was seen in most (93%) of the patients between 4~8 weeks.

tonic_image3

Increase in Hair Growth

Increase in the Hair growth effect was seen in most (95%) of the patients between 8~16 weeks.

tonic_image4

Verification of JW12 mechanism made using seaweeds and natural medicinal herbs

[ IGF-1, TGF-β1 Analysis of expression level) ]

1_contents
Figure 11. PCR and electrophoresis
ⓐ negative control group
ⓑ solvent control
ⓒ experimental group 1
ⓓ experimental group 2
ⓔ JW12

Industry-academy-research final report in April, 2007

Looking at the results of JW12, expression level of growth hormone IGF-1 was higher in comparison to the control group. Expression of TGF-β1 which disturbs the growth of hair was lower compared to the control group. This shows acceleration of hair growth incited by JW12.

Development of medical device (alopecia prevention / hair growth) using seaweeds and natural medicinal herbs ofJW12

Anti-oxidant effect (DPPH suppression)

기술력2_27
Fig 7. Scanvenging effects of DPPH by JW12
About 90% of the DPPH extinction rate was verified at the final concentration of 10%, showing a strong antioxidant
effect of JWDP.

Inflammation (Interlukin-6 suppression rate)

기술력2_30
Fig 6. Inhibitory effects of inflammatory cytokine (IL-6) for JW12
There was no cell toxity at a final concentration of 1%,
and the IL-6 suppression rate was about 46%.

Suppression of protein which controls hair growth cycle (TGF-β2 suppression effect)

①TGF-β2 suppression Effect in HaCat cell

기술력2
Figure 1. RT-PCR products by specific primer for TGF-β2
Expression of TGF-β2 was verified in the group that did
not use JW12 in HaCaT, but the group with 1% JW12
suppressed an expression of TGF-β2.

Suppression of protein which controls hair growth cycle (TGF-β2 suppression effect) 2

②TGF-β2 suppression Effect in HHDPC cell

기술력3
Figure 1. RT-PCR products by specific primer for TGF-β2
In the HHDPC cell group with 0.1% and 1% concentration,
increased concentration resulted in a lower expression.
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Copyright (C) 2015 JWBIO. co. Ltd. All Right Reserved.

A differentiated effect of the Low-Temperature
Nano-Extraction method!

Low temperature nano-extraction Technology!

The JW brands are oriented towards the highest products in the world.

Major Study History

주요 연구이력
Items Contents
Publication of a research paper in Recent Medicine Topical application of JW12 and DANISS and its impact on hair loss prevention and hair growth for alopecia patients
Research Consortium of Industry-Academy-Research Co-op (Catholic Medical University of Daegu) JW12 or DANISS made from Algae and natural herb, their extraction of bioactive substances with hair restorer functionality and the validation of their clinical efficacy
Publication of a research paper in Recent Medicine Hair growth effect of JW12in the Mouse Model
Research Consortium of Industry-Academy-Research Co-op (Catholic Medical University of Daegu) the validation of hair growth mechanism of JW12 and DANISS, which has been developed for hair loss prevention and hair tonic, comparison with existing hair restorers, and application to actual patients
Symposium of the Korean Society of Plastic and Reconstructive Surgeons Presentation on the development and validation of JW12 , hair loss prevention
Gyeongbuk Marine Bio Technology Development (Kyunghee University) Development of the sanitary aid(hair loss prevention/ hair tonic/ hair growth solution) using algae and herb
Publication of a research paper in Recent Medicine
(Catholic Medical University of Daegu)		 Component Analysis of JW12 hair growth solution made from natural herb, extraction of hair growth accelerator, causal Analysis of hair growth, mouse models, and efficacy verification from actual patients
Publication of a research paper in Recent Medicine
(Catholic Medical University of Daegu)		 Analysis of the development and its effects of JW Tonic added with Copper peptide complex
Publication of a research paper in Recent Medicine
(Catholic Medical University of Daegu)		 Effective material extraction and the development of new hair restorer through the combination and analysis of major components of JW Tonic
Publication of a research paper in Recent Medicine
(Catholic Medical University of Daegu)		 Development of a new JW Tonic that is added with a hair growth factor and Validation of hair growth efficacy
Publication of a research paper in Recent Medicine
(Catholic Medical University of Daegu)		 the development and commercialization of hair loss prevention food through ultrasonic extraction
RIC(Regional Innovation Center) Common Task
(Catholic Medical University of Daegu)		 Functional materialization of seaweed polysaccharides and industrialization of through Ultra-high enzymatic extraction – anger extracted

The effect of a topical spray of JW12 and Daniss for the prevention of the hair loss and the promotion of the hair growth of the alopecia patients.(Sebum and dandruff removal, alopecia prevention, hair growth effect)

Recent Medicine, Vol. 47 Issue 7 (Professor Park, Dae Hwan, College of Medicine, Catholic University of Daegu)

Sebum and dandruff removal effect

Among 58 male and female subjects who participated in the clinical study, excessive sebum and dandruff were removed in most of the subjects within 2~3 weeks of use. After one month of use, all subjects showed normal status.

tonic_image1

Reduction in hair loss

Within 2~3 weeks, most (93%) of subjects showed significant reduction in hair loss.

tonic_image2

Hair growth

Hair growth effect with the thickening of hair was seen in most (93%) of the patients between 4~8 weeks.

tonic_image3

Increase in Hair Growth

Increase in the Hair growth effect was seen in most (95%) of the patients between 8~16 weeks.

tonic_image4

Verification of JW12 mechanism made using seaweeds and natural medicinal herbs

[ IGF-1, TGF-β1 Analysis of expression level) ]

1_contents
Figure 11. PCR and electrophoresis
ⓐ negative control group
ⓑ solvent control
ⓒ experimental group 1
ⓓ experimental group 2
ⓔ JW12

Industry-academy-research final report in April, 2007

Looking at the results of JW12, expression level of growth hormone IGF-1 was higher in comparison to the control group. Expression of TGF-β1 which disturbs the growth of hair was lower compared to the control group. This shows acceleration of hair growth incited by JW12.

Development of medical device (alopecia prevention / hair growth) using seaweeds and natural medicinal herbs ofJW12

Anti-oxidant effect (DPPH suppression)

기술력2_27
Fig 7. Scanvenging effects of DPPH by JW12
About 90% of the DPPH extinction rate was verified at the final concentration of 10%, showing a strong antioxidant
effect of JWDP.

Inflammation (Interlukin-6 suppression rate)

기술력2_30
Fig 6. Inhibitory effects of inflammatory cytokine (IL-6) for JW12
There was no cell toxity at a final concentration of 1%,
and the IL-6 suppression rate was about 46%.

Suppression of protein which controls hair growth cycle (TGF-β2 suppression effect)

①TGF-β2 suppression Effect in HaCat cell

기술력2
Figure 1. RT-PCR products by specific primer for TGF-β2
Expression of TGF-β2 was verified in the group that did
not use JW12 in HaCaT, but the group with 1% JW12
suppressed an expression of TGF-β2.

Suppression of protein which controls hair growth cycle (TGF-β2 suppression effect) 2

②TGF-β2 suppression Effect in HHDPC cell

기술력3
Figure 1. RT-PCR products by specific primer for TGF-β2
In the HHDPC cell group with 0.1% and 1% concentration,
increased concentration resulted in a lower expression.